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Homoeopathy scores a point of advantage as this system has the relationship between the drugs and the personality patterns of the patients.With the knowledge of endocrinology, we learn about the hormones of different ductless glands, and their influence over mental& biological make up of the individual.Different glands have different functions but they seem to act synergistically. Very often the disordered functions of one gland with hypo or hyper functions puts us out of tract in selection of a "totality based similar drug". But study of case does indicate as simillimum.